O14 ‐ Der p 10 as a minor allergen in children sensitised to house dust mites
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منابع مشابه
O14 - Der p 10 as a minor allergen in children sensitised to house dust mites
Results We studied 232 children (147 M/85 F) aged 1.25 16.7 years. Negative results were found in 50 (21.6%) with Der p 1, 53 (22.8%) with Der p 2, 208 (89.7%) with Der p 10, and 29 with all three (12.5%). There were 24 patients with positive IgE to Der p 10: three of these had IgE values of 6.1 to 11 kUA/L to Der p 10 and negative results to Der p 1 and 2 (0.1 to 0.18), three had much higher I...
متن کاملExtraction of house dust mite allergen, Der p 1, from dust.
A recent article in this journal found that the type of extraction buffer did not affect measured levels of the major group one allergen (Der p 1) from the house dust mite, Dermatophagoides pteronyssinus, in household dust samples (1). This differed from a previous study where about twice the levels of Der p 1 were found in borate-buffered saline extracts, compared to ammonium bicarbonate buffe...
متن کاملConversion of Der p 23, a new major house dust mite allergen, into a hypoallergenic vaccine.
Der p 23, a new, major house dust mite (HDM) allergen that is recognized by >70% of HDM-allergic patients, has high allergenic activity and, therefore, must be considered an important component for HDM-specific immunotherapy. We constructed and characterized a hypoallergenic Der p 23 vaccine for HDM immunotherapy. Three nonallergenic peptides from the C-terminal IgE epitope-containing part of D...
متن کاملVariation in allergen content in sublingual allergen immunotherapy with house dust mites
BACKGROUND Allergen immunotherapy is a treatment modality which can be applied using different vaccines. The aim of this study was to quantify and compare the allergen content of different house dust mites (HDM)' sublingual treatments and to review the evidence on their efficacy. METHODS Five sublingual allergen immunotherapy (SLIT) products were ordered and purchased at an ordinary pharmacy ...
متن کاملMolecular, Structural and Immunological Characterization of Der p 18, a Chitinase-Like House Dust Mite Allergen
BACKGROUND The house dust mite (HDM) allergen Der p 18 belongs to the glycoside hydrolase family 18 chitinases. The relevance of Der p 18 for house dust mite allergic patients has only been partly investigated. OBJECTIVE To perform a detailed characterization of Der p 18 on a molecular, structural and immunological level. METHODS Der p 18 was expressed in E. coli, purified to homogeneity, t...
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ژورنال
عنوان ژورنال: Clinical and Translational Allergy
سال: 2014
ISSN: 2045-7022,2045-7022
DOI: 10.1186/2045-7022-4-s1-o14